Semaglutide and PCOS
Semaglutide: A Promising New Treatment for PCOS
Introduction
Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting up to 10% of women of reproductive age. Characterized by irregular menstrual cycles, hyperandrogenism, and polycystic ovaries, PCOS often leads to significant metabolic complications, including insulin resistance, obesity, and an increased risk of type 2 diabetes. Semaglutide has recently emerged as a promising treatment for patients with PCOS.
Understanding PCOS and Its Metabolic Challenges
PCOS is not only a reproductive disorder but also a metabolic one. Women with PCOS often experience:
Insulin Resistance: A significant majority of women with PCOS have insulin resistance, which can lead to type 2 diabetes if not managed effectively. By activating GLP-1 receptors, semaglutide enhances insulin sensitivity, helping to lower blood glucose levels and mitigate insulin resistance.
Obesity: Weight gain and difficulty losing weight are common challenges due to metabolic inefficiencies and hormonal imbalances. Based on most recent clinic trials, patients lose on average 26.6% of their total body weight. Weight reduction can improve ovulatory function and reduce hyperandrogenism.
Hyperandrogenism: Elevated levels of androgens can cause symptoms like hirsutism (excess hair growth), acne, and alopecia. By addressing the underlying metabolic issues, semaglutide can help lower androgen levels, reducing symptoms like hirsutism and acne.
Cardiovascular Risk: The metabolic disturbances associated with PCOS increase the risk of cardiovascular diseases. Semaglutide has been associated with improvements in cardiovascular risk markers
Decreased Fertility: PCOS causes menstrual irregularities and metabolic imbalances that can affect fertility. Weight loss and improved insulin sensitivity can enhance ovulatory function, increasing the chances of conception for women with PCOS.
Important information to Remember: Pregnancy while taking semaglutide is not recommend. You must use contraception while on semaglutide and for 2 month following discontinuation. Semaglutide can take up to 2 months to fully clear out of the system. Our providers will discuss this with you in detail at your initial consult should you be utilizing tirzepatide to improve fertility, as you must stop medication 2 months prior to trying to conceive.